Pakistan finished the day at 201/4, 85 runs in arrears after West Indies put up a first innings total of 286.
Just 11.3 overs were bowled on Day 2 as West Indies finished at 278/9 with captain Holder fighting on at 55*.
The hosts finished at 244/7 after 63 by Roston Chase and 56 from Shane Dowrich - three wickets for Mohammad Amir and two for Yasir Shah.
Writing in his exclusive blog for PakPassion.net, the renowned West Indies cricket commentator looks forward to the upcoming Test series between West Indies and Pakistan and wonders if the visitors have the resolve and the resources to complete a first ever Test victory in the Caribbean.
Mohammad Hafeez hit 80 while Shoaib Malik made an unbeaten hundred as visitors easily chased down target of 234.
The former hit an unbeaten 125 to guide Pakistan to 282/5 while the latter took 5/38 as the visitors sealed a 74-run victory.
In an exclusive interview with PakPassion.net, Usman Salahuddin spoke about his patient wait for another chance to represent Pakistan since his ODI debut in 2011, the golden opportunity to establish himself as a replacement for the retiring Misbah-ul-Haq and Younis Khan and also praised the selectors for their efforts to pick top domestic performers.
Hosts chased down target of 300+ for the first time in ODIs, getting to 309 with four wickets and an over to spare.
Ahmed Shehzad's fifty helped visitors to chase down 125 after Hasan Ali and Shadab Khan took two wickets apiece to limit hosts to a below-par total.